Several recent studies have proposed the clinical use of atypical antipsychotics for the treatment of patients with post-traumatic stress disorder and borderline personality disorder who experience severe AVHs. Hence, there is a dire need for researchers to explore the efficacy of current treatment options and the effects of atypical antipsychotics on the associated brain functional alterations in patients with AVHs because this information may be useful in helping physicians optimize future therapies. 1 – 5 Because of the adverse effects that AVHs have on patients’ mental health, some clinicians and researchers have expressed an urgent need for treating these patients. 1 – 3 Serious AVHs can impact multiple neurological functions in Hi-AVHs, which may result in an increased risk of violence, the development of specific disabilities, and potentially death in some individuals.
Although the prevalence of Hi-AVHs in the healthy population has been debated, the estimated prevalence ranges from 0.7% (based on the strictest diagnostic criteria) to 4.0%. AVHs are often harmful because they can negatively impact patients’ social functioning and mental health, which may lead to self-harm and suicide in extreme cases. These healthy individuals with AVHs (Hi-AVHs) have been termed non-clinical AVH subjects.
While rare, there have also been reports of AVHs in healthy individuals who show no other signs of psychiatric illness or history of mental illness. This phenomenon is often associated with mental disorders such as schizophrenia, bipolar disorder, borderline personality disorder, major depressive disorder, and post-traumatic stress disorder. Auditory verbal hallucinations (AVHs) are defined as the experience of hearing spoken words or sounds in the absence of an actual speaker.
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